Cached write/uncached read.
#define PRL_DISK_CACHE_UNCACHED_READ 3
PrlDisk.h
Like DISK_CACHE_ENABLED, but read data does not duplicated in host OS RAM, so you have more RAM for host applications. On Mac you may also see performance gain when you read data that were just written before and held in OS cache - data will be read from cache even with F_NOCACHE read(). This may help guest OS with stuff like pagefile.sys for example.